Weight loss prior to diagnosis of first-episode psychosis predicts subsequent weight gain: a retrospective cohort study of the UK Clinical Practice Research Datalink (CPRD) primary care database - Takeaways - MDSpire

Weight loss prior to diagnosis of first-episode psychosis predicts subsequent weight gain: a retrospective cohort study of the UK Clinical Practice Research Datalink (CPRD) primary care database

  • By

  • Brian O’Mahony

  • Richard I G Holt

  • Emanuele F Osimo

  • Karla V.B Hitchins

  • Brian O’Donoghue

  • Benjamin I Perry

  • July 16, 2026

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  • 1

    53% of individuals experienced weight loss prior to the diagnosis of first-episode psychosis (FEP).

  • 2

    Individuals with pre-FEP weight loss gained weight post-FEP at over twice the rate of those without prior loss.

  • 3

    Each 1% of pre-FEP weight loss predicted an additional 0.41% annual weight gain after diagnosis.

  • 4

    Average weight gain post-FEP (6.49 kg) exceeded average prior weight loss (4.83 kg) by one year.

  • 5

    Findings suggest that pre-FEP weight loss is common and significantly predicts rapid post-diagnosis weight gain.

Original Source(s)

Weight loss prior to diagnosis of first-episode psychosis predicts subsequent weight gain: a retrospective cohort study of the UK Clinical Practice Research Datalink (CPRD) primary care database

  • by Brian O’Mahony, Richard I G Holt, Emanuele F Osimo, Karla V.B Hitchins, Brian O’Donoghue, Benjamin I Perry

  • July 16, 2026

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