Effective Recovery of a PICC Line in a Catheter-Related Bloodstream Infection Due to Multidrug-Resistant Ralstonia mannitolilytica with Topical Minocycline: A Case Study

1

Ralstonia mannitolilytica is a multidrug-resistant pathogen causing catheter-related bloodstream infections with limited treatment options.
2

A 47-year-old female with brain death developed a PICC-related bloodstream infection due to Ralstonia mannitolilytica after catheter insertion.
3

Initial treatment with systemic antibiotics failed, and the family refused catheter removal, prompting the use of topical minocycline.
4

Topical minocycline combined with standardized catheter care successfully controlled the infection, allowing retention of the PICC.
5

The case highlights the potential of topical antimicrobial therapy in managing CRBSI caused by multidrug-resistant bacteria.

Bmc Infectious Diseases

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