Brain cell-released Cyclophilin A induces neuroinflammation and exacerbates blood–brain barrier injury in acute ischemic stroke - Takeaways - MDSpire

Brain cell-released Cyclophilin A induces neuroinflammation and exacerbates blood–brain barrier injury in acute ischemic stroke

  • By

  • Enyue Chen

  • Qihui Wu

  • Yunwen Xue

  • Shixiong Huang

  • Yong Gu

  • June 18, 2026

  • 0 min

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  • 1

    Cyclophilin A (CypA) is released by brain cells during acute ischemic stroke, contributing to neuroinflammation and blood-brain barrier (BBB) damage.

  • 2

    Elevated levels of extracellular CypA (eCypA) were found in serum and cerebrospinal fluid of acute ischemic stroke patients and in experimental models.

  • 3

    The CypA inhibitory peptide C46 improved neurological function and reduced cerebral infarct volume in rat models of acute ischemic stroke.

  • 4

    C46 administration mitigated BBB permeability and preserved tight junction protein expression in both in vivo and in vitro studies.

  • 5

    Targeting eCypA with C46 may represent a novel therapeutic approach for addressing neuroinflammation and BBB disruption in acute ischemic stroke.

Original Source(s)

Brain cell-released Cyclophilin A induces neuroinflammation and exacerbates blood–brain barrier injury in acute ischemic stroke

  • by Enyue Chen, Qihui Wu, Yunwen Xue, Shixiong Huang, Yong Gu

  • June 18, 2026

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