Abnormal Cardiac Magnetic Resonance Imaging Mapping Parameters in Pediatric Heart Transplant Patients with Elevated Donor-Derived Cell Free DNA - Takeaways - MDSpire
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Altered Cardiac MRI Mapping Metrics in Pediatric Heart Transplant Recipients with Increased Levels of Donor-Derived Cell-Free DNA

  • By

  • Kae Watanabe

  • Defne A. Magnetta

  • Christina Laternser

  • Alona Birjiniuk

  • Joshua D. Robinson

  • Cynthia K. Rigsby

  • Nazia Husain

  • July 9, 2026

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  • 1

    Heart transplant is the gold standard for end-stage heart failure in pediatric patients.

  • 2

    Donor-derived cell-free DNA (ddcfDNA) is increasingly used for non-invasive rejection surveillance in heart transplant recipients.

  • 3

    Multiparametric cardiac magnetic resonance imaging (CMR) allows comprehensive tissue characterization of the myocardium.

  • 4

    The study included 68 pediatric heart transplant patients, with 54 in the low ddcfDNA group and 14 in the high group.

  • 5

    Higher levels of ddcfDNA were associated with older age, increased history of cardiac allograft vasculopathy, and moderate/severe rejection.

Original Source(s)

Abnormal Cardiac Magnetic Resonance Imaging Mapping Parameters in Pediatric Heart Transplant Patients with Elevated Donor-Derived Cell Free DNA

  • by Kae Watanabe, Defne A. Magnetta, Christina Laternser, Alona Birjiniuk, Joshua D. Robinson, Cynthia K. Rigsby, Nazia Husain

  • July 9, 2026

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