Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China - Takeaways - MDSpire
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Associations Between Thyroid Hormones, Sensitivity Indices, Volumetric Bone Mineral Density, and Vertebral Fracture Risk in Osteoporotic Individuals in Northern China

  • By

  • Zhou Meicen

  • Deng Wei

  • Wang Yanai

  • Huo Lili

  • Gao Tan

  • Chen Jia

  • June 4, 2026

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  • 1

    Thyroid hormones, particularly TT3 and FT4/FT3, are significantly associated with vertebral fracture risk and bone mineral density in osteoporotic individuals.

  • 2

    The study involved 1,386 euthyroid osteoporotic participants aged over 50, divided into groups based on vertebral fracture status.

  • 3

    Higher TT3 levels were linked to increased vertebral fracture risk, while lower TT4 levels were observed in the fracture group compared to non-fracture individuals.

  • 4

    TSH was positively associated with lumbar volumetric bone mineral density, indicating its potential protective role against osteoporosis.

  • 5

    The findings suggest that thyroid hormone sensitivity indices may serve as important indicators for predicting bone mass and fracture risk.

Original Source(s)

Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China

  • by Zhou Meicen, Deng Wei, Wang Yanai, Huo Lili, Gao Tan, Chen Jia

  • June 4, 2026

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