Clinical outcomes of tibial cortex transverse transport versus antibiotic-loaded bone cement for Wagner grade 3–4 diabetic foot ulcers: a real-world retrospective cohort study - Takeaways - MDSpire

Clinical outcomes of tibial cortex transverse transport versus antibiotic-loaded bone cement for Wagner grade 3–4 diabetic foot ulcers: a real-world retrospective cohort study

  • By

  • Muhan Li

  • Chenghao Zhu

  • Zhongxian Xu

  • Xiwen Feng

  • Guangming Zheng

  • Yongjun Li

  • June 3, 2026

  • 0 min

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  • 1

    Diabetic foot ulcers (DFUs) are a leading cause of non-traumatic lower-extremity amputations, particularly Wagner grade 3–4 ulcers.

  • 2

    Antibiotic-loaded bone cement (ALBC) focuses on infection control and dead-space management, while tibial cortex transverse transport (TTT) enhances perfusion.

  • 3

    In a retrospective study, TTT showed a higher percentage area reduction at 6 months for Wagner grade 4 DFUs compared to ALBC.

  • 4

    TTT was associated with a lower rate of unplanned return to the operating room and greater improvement in ankle-brachial index compared to ALBC.

  • 5

    ALBC was linked to faster infection clearance, suggesting that treatment selection for DFUs should be individualized based on clinical priorities.

Original Source(s)

Clinical outcomes of tibial cortex transverse transport versus antibiotic-loaded bone cement for Wagner grade 3–4 diabetic foot ulcers: a real-world retrospective cohort study

  • by Muhan Li, Chenghao Zhu, Zhongxian Xu, Xiwen Feng, Guangming Zheng, Yongjun Li

  • June 3, 2026

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