Huoxue Jiegu compound capsule accelerates tibial fracture healing via angiogenesis-driven repair mechanisms

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Huoxue Jiegu Compound Capsule (HXJGCC) enhances tibial fracture healing by promoting angiogenesis and improving the local microvascular environment.
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Network pharmacology identified 209 active compounds and 185 overlapping targets, highlighting key angiogenesis-related signaling pathways.
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Key targets such as AKT1, STAT3, and IL6 were enriched in angiogenesis pathways, indicating their role in fracture repair mechanisms.
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In vivo experiments demonstrated that HXJGCC significantly increased vascular density and improved vascular architecture in the fracture region.
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The study supports an angiogenesis-driven repair framework, integrating neuro-vascular-bone interactions to enhance bone regeneration.

Frontiers In Medicine

by Weisong Lu, Bin Pu, Dong Wang, Shixiang Tan, Yingjie Wu, Yangzhan Sun, Mengze Li, Hegui Xu
May 11, 2026

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