Prediction model for early neurological deterioration in large artery atherosclerotic stroke - Takeaways - MDSpire

Prediction model for early neurological deterioration in large artery atherosclerotic stroke

  • By

  • Lele Feng

  • Chuanzhuo Zhang

  • Jiayu Zhou

  • Xinyi Zhang

  • Jingyi Guo

  • Benping Zhang

  • July 9, 2026

  • 0 min

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  • 1

    A predictive model for early neurological deterioration (END) in acute ischemic stroke was developed and validated using data from 433 patients.

  • 2

    END was defined as an NIHSS increase of ≥2 points within 7 days, occurring in 27.1% of the training cohort and 26.9% of the validation cohort.

  • 3

    Seven variables were identified, with six being independent predictors of END: neutrophil count, platelet count, lymphocyte count, fasting plasma glucose, total cholesterol, and D-dimer.

  • 4

    The model demonstrated good performance with an AUC of 0.791 in the training cohort and 0.778 in the internal validation cohort.

  • 5

    Calibration curves indicated acceptable fit, and the model may assist in early identification of high-risk patients for individualized treatment decisions.

Original Source(s)

Prediction model for early neurological deterioration in large artery atherosclerotic stroke

  • by Lele Feng, Chuanzhuo Zhang, Jiayu Zhou, Xinyi Zhang, Jingyi Guo, Benping Zhang

  • July 9, 2026

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