The metabolic syndrome-cancer axis: global research trends and clinical landscapes - Takeaways - MDSpire

The metabolic syndrome-cancer axis: global research trends and clinical landscapes

  • By

  • Dianzhe Tian

  • Xinshi Li

  • Jiajie Lin

  • Zuyi Yang

  • Xinyu Zhao

  • Zixuan Hu

  • Haitao Zhao

  • Shunda Du

  • Shengzhi Liu

  • Lei Zhang

  • Yiyao Xu

  • Xin Lu

  • June 22, 2026

  • 0 min

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  • 1

    Research on the link between metabolic syndrome (MetS) and cancer has increased significantly, primarily driven by contributions from China and the US.

  • 2

    The thematic focus of MetS research has evolved from isolated metabolic issues to integrated approaches involving cancer prognosis and interventions.

  • 3

    Bioinformatics analysis identified hub genes and pathways that connect metabolic dysregulation with tumor development, particularly through inflammation and insulin signaling.

  • 4

    MetS is associated with poorer oncologic outcomes, including higher recurrence rates and reduced survival, highlighting its role as a significant cancer risk factor.

  • 5

    Current research on MetS and cancer is fragmented, indicating a need for a systematic bibliometric approach to map knowledge gaps and emerging trends.

Original Source(s)

The metabolic syndrome-cancer axis: global research trends and clinical landscapes

  • by Dianzhe Tian, Xinshi Li, Jiajie Lin, Zuyi Yang, Xinyu Zhao, Zixuan Hu, Haitao Zhao, Shunda Du, Shengzhi Liu, Lei Zhang, Yiyao Xu, Xin Lu

  • June 22, 2026

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