Mycoplasma pneumoniae pneumonia with and without viral pathogens in preschool-aged children: a comparative study of clinical outcomes

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Viral co-detection occurred in 38.3% of children hospitalized with Mycoplasma pneumoniae pneumonia, peaking in the 2–4 years age group.
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Co-detection in children under 2 years was linked to a higher severe disease rate of 29.7% compared to 9.5% in older children.
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Human metapneumovirus and respiratory syncytial virus co-detections were associated with more pronounced inflammatory responses than rhinovirus co-detection.
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HMPV co-detection was characterized by leukopenia and elevated IL-10 and IFN-γ levels, while RSV co-detection featured a neutrophilic response.
5

Multivariable analysis identified wheezing, severe pneumonia, and higher serum IL-10 as independent risk factors associated with viral co-detection.

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