Papillary thyroid carcinoma with brain and lung metastases: a case report

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Papillary thyroid carcinoma (PTC) can lead to rare and delayed metastases, as demonstrated by a case with brain and lung involvement six years post-surgery.
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A 61-year-old female presented with speech impairment and limb weakness, revealing metastatic thyroid cancer after a total thyroidectomy for PTC.
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Diagnostic imaging showed a solitary brain mass and multiple lung nodules, confirmed as metastatic thyroid cancer through biopsies.
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The patient experienced extreme toxicity from chemotherapy, leading to a switch to the multi-kinase inhibitor anlotinib, which resulted in partial remission.
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This case underscores the need for lifelong surveillance in PTC patients and highlights anlotinib's potential as a therapeutic option for resistant metastases.

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