Relationship between MLH1, MSH2, MSH6, and PMS2 protein expression status and clinicopathological characteristics in colorectal cancer tissues - Takeaways - MDSpire

Relationship between MLH1, MSH2, MSH6, and PMS2 protein expression status and clinicopathological characteristics in colorectal cancer tissues

  • By

  • Hu, Wansheng

  • Hu, Xiaowei

  • Xie, Enyun

  • Wang, Yanyan

  • May 26, 2026

  • 0 min

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  • 1

    The study assessed dMMR protein deficiency in 80 Chinese colorectal cancer patients using immunohistochemistry.

  • 2

    22.5% of patients were identified as dMMR, with isolated PMS2 loss being the most common deficiency pattern.

  • 3

    dMMR colorectal cancers were more likely to be located in the right colon and exhibit poor differentiation and mucinous histology.

  • 4

    dMMR status was associated with a lower rate of lymph node metastasis compared to pMMR cases.

  • 5

    Routine IHC-based MMR testing is recommended, with further molecular testing needed to differentiate dMMR causes.

Original Source(s)

Relationship between MLH1, MSH2, MSH6, and PMS2 protein expression status and clinicopathological characteristics in colorectal cancer tissues

  • by Hu, Wansheng , Hu, Xiaowei , Xie, Enyun , Wang, Yanyan

  • May 26, 2026

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