Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden - Takeaways - MDSpire

Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden

  • By

  • Jin-Xuan Zheng

  • Hui Jin

  • Shu-Jing Hu

  • Shan-Shan Zhu

  • Shun-Yao Xu

  • May 4, 2026

  • 0 min

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  • 1

    The study identified two distinct sleep-disordered breathing phenotypes in older adults with depression and obstructive sleep apnea-hypopnea syndrome.

  • 2

    The high-hypoxia/severe OSAHS phenotype exhibited higher BMI, depressive symptoms, and more severe apnea-hypopnea indices compared to the lower-hypoxia phenotype.

  • 3

    Participants in the high-hypoxia/severe OSAHS phenotype had significantly elevated levels of inflammatory markers such as hs-CRP, IL-6, and TNF-α.

  • 4

    The inflammatory burden score was notably higher in the high-hypoxia/severe OSAHS phenotype, indicating a greater systemic inflammatory response.

  • 5

    The findings suggest that sleep-disordered breathing phenotypes in older adults with depression are associated with varying levels of systemic inflammation.

Original Source(s)

Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden

  • by Jin-Xuan Zheng, Hui Jin, Shu-Jing Hu, Shan-Shan Zhu, Shun-Yao Xu

  • May 4, 2026

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