Investigation of ACOD1 Levels in Sepsis Patients: Correlations with Disease Severity and Immune Profiles - Takeaways - MDSpire

Investigation of ACOD1 Levels in Sepsis Patients: Correlations with Disease Severity and Immune Profiles

  • By

  • Huiwen Xiong

  • Yi Zhao

  • Yuxuan Yang

  • Yanshi Wang

  • Ren Guo

  • Zuoliang Liu

  • February 25, 2026

  • 0 min

Share

  • 1

    Sepsis is a complex syndrome characterized by dysregulated inflammation, immune dysfunction, and acute organ dysfunction.

  • 2

    ACOD1 is an enzyme that regulates immunometabolic reprogramming and is crucial for itaconate synthesis in inflammatory responses.

  • 3

    The study analyzed ACOD1 expression levels in septic patients using datasets from the GEO database to explore its clinical relevance.

  • 4

    ACOD1 expression correlates with clinical indicators like SOFA score, DIC score, and 28-day survival in sepsis patients.

  • 5

    Understanding ACOD1's role may provide insights into immune homeostasis and potential biomarkers for sepsis severity.

Original Source(s)

Investigation of ACOD1 Levels in Sepsis Patients: Correlations with Disease Severity and Immune Profiles

  • by Huiwen Xiong, Yi Zhao, Yuxuan Yang, Yanshi Wang, Ren Guo, Zuoliang Liu

  • February 25, 2026

Related Content

Acute liver failure and secondary TMA-like phenomenon following SARS-CoV-2 and Mycoplasma pneumoniae co-detection in a child: a case report

Characteristics and outcomes of type 2 myocardial infarction in sepsis survivors

Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study