A rare inherited variant in the MET gene may cause steatotic liver disease in some patients, as reported in a study published in Hepatology.
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The study suggests that a single genetic alteration can drive disease development, differing from the typical combination of metabolic and environmental factors.
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Researchers identified a germline variant in the MET gene in a family with steatohepatitis who lacked typical metabolic risk factors.
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Functional analyses indicated that disruption of MET signaling affects hepatocyte lipid metabolism, leading to fat accumulation and inflammation.
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The study marks the first report of a germline, nonmalignant MET-driven monogenic form of steatotic liver disease, warranting further research.
