fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study - Takeaways - MDSpire

fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study

  • By

  • Xudong Zhao

  • Hetong Zhou

  • Xiaomei Zhang

  • Ruoyu Tang

  • Yimei Gan

  • Tongjie Zhuang

  • Yiyi Zhu

  • Zeyu Qin

  • Yiqing Chen

  • Yaoyang Fu

  • Danhua Zhang

  • Le Xu

  • Shiliang Wang

  • Zhongxia Shen

  • Shaohua Hu

  • Minmin Wang

  • March 7, 2026

  • 0 min

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  • 1

    Bipolar disorder in young individuals significantly disrupts emotional regulation and psychosocial functioning, necessitating effective treatment options.

  • 2

    Repetitive transcranial magnetic stimulation (rTMS) targeting the orbitofrontal cortex has shown promise in alleviating treatment-resistant depression.

  • 3

    This study utilized fMRI-guided high-frequency rTMS over the primary visual cortex (V1) to indirectly modulate orbitofrontal cortex circuits.

  • 4

    A double-blind, randomized controlled trial was conducted to evaluate the efficacy of V1-targeted rTMS in reducing depressive symptoms.

  • 5

    Results indicated significant improvements in depression scores, suggesting V1-targeted rTMS may be a viable treatment for bipolar depression.

Original Source(s)

fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study

  • by Xudong Zhao, Hetong Zhou, Xiaomei Zhang, Ruoyu Tang, Yimei Gan, Tongjie Zhuang, Yiyi Zhu, Zeyu Qin, Yiqing Chen, Yaoyang Fu, Danhua Zhang, Le Xu, Shiliang Wang, Zhongxia Shen, Shaohua Hu, Minmin Wang

  • March 7, 2026

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