The pathogenesis and surgical treatment progress of gastroesophageal reflux disease - Takeaways - MDSpire

The pathogenesis and surgical treatment progress of gastroesophageal reflux disease

  • By

  • Longmiao Gu

  • Fan Wu

  • Jie Cheng

  • Xiaojun Shen

  • May 25, 2026

  • 0 min

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  • 1

    Gastroesophageal reflux disease (GERD) is prevalent globally, with North America having the highest rates at 19.6%.

  • 2

    The pathogenesis of GERD involves dysfunction of the lower esophageal sphincter and other anatomical factors.

  • 3

    Surgical intervention is necessary for patients with severe GERD symptoms or complications, despite effective pharmacological therapies.

  • 4

    Minimally invasive surgical techniques, including robot-assisted surgery and magnetic sphincter augmentation, have advanced recently.

  • 5

    The concept of 'asymptomatic elective repair' for hiatal hernia patients requires further exploration in the context of GERD.

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