Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age - Takeaways - MDSpire

Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age

  • By

  • Nuzhat Parveen

  • Naveed Iqbal

  • Abdelrahim Awadelkarim Abdelrahman Mohamed

  • Syed Monowar Alam Shahid

  • Rania Abdeen Hussain Abdalla

  • Gamal Eldin Mohamed Osman Elhussein

  • Mohammad Asim Azhar

  • Mohd. Saleem

  • Mohd Shahid Khan

  • May 26, 2026

  • 0 min

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  • 1

    This study evaluated adiponectin and leptin levels in mothers, fetuses, and newborns with intrauterine growth restriction (IUGR) compared to appropriate-for-gestational-age (AGA) pregnancies.

  • 2

    Adiponectin levels were significantly reduced in maternal and neonatal blood in the IUGR group, while no significant difference was found in umbilical cord blood.

  • 3

    Leptin levels were increased in umbilical cord blood and decreased in neonatal blood in the IUGR group, with maternal levels being comparable between groups.

  • 4

    Placental analysis showed significant downregulation of ADIPOQ and altered expression of LEP and WFS1 genes in IUGR pregnancies.

  • 5

    DNA methylation analysis revealed increased methylation of ADIPOQ and LEP genes in placental tissue, inversely related to gene expression.

Original Source(s)

Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age

  • by Nuzhat Parveen, Naveed Iqbal, Abdelrahim Awadelkarim Abdelrahman Mohamed, Syed Monowar Alam Shahid, Rania Abdeen Hussain Abdalla, Gamal Eldin Mohamed Osman Elhussein, Mohammad Asim Azhar, Mohd. Saleem, Mohd Shahid Khan

  • May 26, 2026

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