Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases - Takeaways - MDSpire

Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases

  • By

  • Olivia C. Ihedioha

  • Diane McMahon-Pratt

  • Alfred L. M. Bothwell

  • June 2, 2026

  • 0 min

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  • 1

    Platelet-derived DKK1 modulates immune responses during Leishmania major infection, influencing chronic inflammation and immune cell interactions.

  • 2

    DKK1 promotes leukocyte-platelet aggregation and recruits immune cells like neutrophils and macrophages to inflammatory sites in infected mice.

  • 3

    The presence of DKK1 favors Th2 and regulatory immune responses, potentially diminishing protective Th1 responses against Leishmania.

  • 4

    Platelet activation and DKK1 release may also play a role in the immunopathology of other infectious diseases beyond leishmaniasis.

  • 5

    This review highlights DKK1 as a potential immunomodulatory target, emphasizing the need for further research on its role in infectious disease management.

Original Source(s)

Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases

  • by Olivia C. Ihedioha, Diane McMahon-Pratt, Alfred L. M. Bothwell

  • June 2, 2026

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