Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study

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The SPISE index is a novel marker of insulin sensitivity that does not require insulin measurement and predicts the risk of impaired fasting glucose (IFG).
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In a study of 100,494 Chinese adults, a higher SPISE index was associated with a lower risk of developing IFG during a median follow-up of 2.99 years.
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Each one-unit increase in the SPISE index correlated with a hazard ratio of 0.91 for incident IFG, indicating a significant protective effect.
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Participants in the highest SPISE index quartile had approximately 40% lower risk of IFG compared to those in the lowest quartile, demonstrating a dose-response relationship.
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The findings suggest that the SPISE index could be a cost-effective tool for identifying individuals at high risk for IFG and implementing diabetes prevention strategies.

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