Repeated administration of autologous tumor-infiltrating lymphocytes (LM103 infusion) alongside immune checkpoint inhibitors results in sustained tumor regression in a patient with advanced mucosal melanoma: a case study and review of existing literature - Takeaways - MDSpire

Repeated administration of autologous tumor-infiltrating lymphocytes (LM103 infusion) alongside immune checkpoint inhibitors results in sustained tumor regression in a patient with advanced mucosal melanoma: a case study and review of existing literature

  • By

  • Fenge Li

  • Yue Xu

  • Yupeng Wang

  • Ning Mu

  • Mei Liu

  • Weihong Feng

  • Yongming Xue

  • Shengnan Wu

  • Xinyi Wang

  • Gregory Lizee

  • Chunhua Ma

  • April 23, 2026

  • 0 min

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  • 1

    Autologous tumor-infiltrating lymphocyte (TIL) therapy shows promise for advanced melanoma patients who have failed prior immunotherapy.

  • 2

    A patient with stage IV nasal mucosal melanoma achieved partial and complete responses after multiple TIL infusions combined with immune checkpoint inhibitors.

  • 3

    The patient experienced tumor relapse but benefited from repeated TIL treatments, demonstrating sustained immune activation and clinical responses.

  • 4

    Manageable adverse events were observed following TIL treatments, indicating a favorable safety profile for this therapy.

  • 5

    This case highlights the potential of multiple TIL therapies and the need for further trials to optimize treatment protocols.

Original Source(s)

Repeated administration of autologous tumor-infiltrating lymphocytes (LM103 infusion) alongside immune checkpoint inhibitors results in sustained tumor regression in a patient with advanced mucosal melanoma: a case study and review of existing literature

  • by Fenge Li, Yue Xu, Yupeng Wang, Ning Mu, Mei Liu, Weihong Feng, Yongming Xue, Shengnan Wu, Xinyi Wang, Gregory Lizee, Chunhua Ma

  • April 23, 2026

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