Elevated plasma cholesterol improves sepsis outcome by promoting hepatic metabolic reprogramming - Takeaways - MDSpire

Elevated plasma cholesterol improves sepsis outcome by promoting hepatic metabolic reprogramming

  • By

  • Qian Wang

  • Jianyao Xue

  • Ling Guo

  • Dan Hao

  • Misa Ito

  • Rianna Reese

  • Bin Huang

  • Congqing Wu

  • Xiang-An Li

  • May 11, 2026

  • 0 min

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  • 1

    Higher plasma cholesterol levels are associated with improved survival rates in sepsis patients, with survivors showing significantly elevated cholesterol compared to non-survivors.

  • 2

    A high-cholesterol diet in mice led to increased plasma cholesterol and significantly improved survival rates during sepsis, indicating a protective effect.

  • 3

    Elevated cholesterol levels are linked to reduced 28-day mortality in sepsis, with an adjusted hazard ratio of 0.80 for cholesterol levels ≥133 mg/dL.

  • 4

    Mechanistic studies revealed that high cholesterol promotes metabolic reprogramming in the liver, enhancing oxidative phosphorylation and antioxidant pathways.

  • 5

    Targeting hepatic bioenergetics may offer new therapeutic strategies for improving outcomes in sepsis, as cholesterol appears to modulate host resilience.

Original Source(s)

Elevated plasma cholesterol improves sepsis outcome by promoting hepatic metabolic reprogramming

  • by Qian Wang, Jianyao Xue, Ling Guo, Dan Hao, Misa Ito, Rianna Reese, Bin Huang, Congqing Wu, Xiang-An Li

  • May 11, 2026

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