Medications May Affect Fracture Healing

Evidence varies by drug class, with limited data on union outcomes

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Common medications show variable effects on fracture healing, with most studies focusing on fracture risk rather than healing outcomes.
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Nonsteroidal anti-inflammatory drugs were the most studied, showing limited effects on healing with prolonged use linked to delayed union.
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Corticosteroids reduced bone formation and altered remodeling, but direct evidence on their impact on fracture healing was limited.
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Metabolic diseases like diabetes were associated with delayed healing, highlighting the role of comorbidities in fracture recovery.
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The review emphasized that medication effects on healing are complex and should consider timing, dosage, and patient characteristics.

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