NAFLD-associated immune remodeling in colorectal cancer liver metastasis: mechanisms and implications for immunotherapy - Takeaways - MDSpire

NAFLD-associated immune remodeling in colorectal cancer liver metastasis: mechanisms and implications for immunotherapy

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NAFLD affects over 30% of adults and is an adverse prognostic factor for colorectal cancer liver metastasis.
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NAFLD-induced lipotoxicity reshapes the hepatic immune microenvironment, promoting colorectal cancer metastatic colonization.
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A hierarchical immunosuppressive network involving CD4+ T cell apoptosis and Treg expansion contributes to immune dysregulation.
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MDSCs recruitment and CD8+ T cell exhaustion are linked to NAFLD, reducing responsiveness to immune checkpoint inhibitors.
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The review highlights potential targets for risk stratification and combination immunotherapy in the NAFLD population.

Frontiers In Immunology

Frontiers In Immunology

Bmj Open Gastroenterology

Journal Of Gastroenterology

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