Commentary: Impact of HPV vaccine on CIN2+ recurrence after conization: a systematic review and meta-analysis of vaccination timing, valency and surgical margins - Takeaways - MDSpire
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Analysis of HPV Vaccination Effects on CIN2+ Recurrence Following Conization: A Systematic Review and Meta-Analysis of Timing, Valency, and Surgical Margins

  • By

  • Mengjie Xue

  • Jihong Peng

  • August 24, 2026

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  • 1

    Maiorano et al. reported a pooled relative risk of 0.38 for CIN2+ recurrence following conization with HPV vaccination, indicating a 62% lower recurrence risk.

  • 2

    The analysis included 17 studies with 33,181 women, but 15 studies were observational, which may introduce healthy user bias.

  • 3

    Re-analysis of four randomized controlled trials yielded a pooled relative risk of 0.56, suggesting a 44% reduction in recurrence.

  • 4

    The original meta-analysis may overestimate the benefit of HPV vaccination due to methodological heterogeneity and underpowered trials.

  • 5

    Future guidelines should report estimates by study design to provide a clearer understanding of the effect magnitude on CIN2+ recurrence.

Original Source(s)

Commentary: Impact of HPV vaccine on CIN2+ recurrence after conization: a systematic review and meta-analysis of vaccination timing, valency and surgical margins

  • by Mengjie Xue, Jihong Peng

  • August 24, 2026

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