Vitrectomy Linked to Higher CME Risk

Large US database study suggests previous pars plana vitrectomy may substantially increase likelihood of pseudophakic cystoid macular edema

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Patients who underwent pars plana vitrectomy (PPV) have a higher risk of developing cystoid macular edema (CME) after cataract surgery.
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A study analyzed 615,983 adults undergoing cataract surgery, with 7,422 having prior PPV, revealing significant CME rates.
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CME occurred in 4.59% of patients with prior PPV compared to 1.23% in those without, indicating a relative risk of 3.73.
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The increased CME risk persisted across different indications for PPV, including retinal detachment and non-retinal-detachment cases.
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The study authors noted potential surveillance bias and acknowledged limitations, including reliance on diagnostic codes and lack of visual-acuity outcomes.

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