Anti-CD146 Linked to Silica in Systemic Sclerosis - Takeaways - MDSpire

Anti-CD146 Linked to Silica in Systemic Sclerosis

Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.

  • By

  • Kathryn Wighton

  • March 5, 2026

  • 3 min

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  • 1

    Anti-CD146 autoantibodies are more frequently detected in systemic sclerosis patients and linked to occupational silica exposure.

  • 2

    In a cohort of 93 systemic sclerosis patients, 15% tested positive for anti-CD146 compared to 5% of healthy donors.

  • 3

    The antibody showed 57% sensitivity and 88% specificity for occupational exposure in the studied cohort.

  • 4

    Among antibody-positive patients, 29% had silica exposure, while only 4% of antibody-negative patients had similar exposure.

  • 5

    The study identifies AACD146 as a potential diagnostic tool for systemic sclerosis related to occupational disease.

Original Source(s)

Anti-CD146 Linked to Silica in Systemic Sclerosis

  • by Kathryn Wighton

  • March 5, 2026

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