Anti-CD146 Linked to Silica in Systemic Sclerosis
Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.
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By
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Kathryn Wighton
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March 5, 2026
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Anti-CD146 autoantibodies are more frequently detected in systemic sclerosis patients and linked to occupational silica exposure.
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In a cohort of 93 systemic sclerosis patients, 15% tested positive for anti-CD146 compared to 5% of healthy donors.
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The antibody showed 57% sensitivity and 88% specificity for occupational exposure in the studied cohort.
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Among antibody-positive patients, 29% had silica exposure, while only 4% of antibody-negative patients had similar exposure.
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The study identifies AACD146 as a potential diagnostic tool for systemic sclerosis related to occupational disease.
