Physical activity and vascular calcification in maintenance hemodialysis: the mediating role of irisin

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Vascular calcification is a significant factor in cardiovascular mortality among patients undergoing maintenance hemodialysis.
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Higher physical activity levels are associated with lower odds of severe vascular calcification in hemodialysis patients.
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Serum irisin levels are inversely related to severe vascular calcification, suggesting a potential mediating role.
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Irisin mediates approximately 60.8% of the association between physical activity and severe vascular calcification.
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The study highlights the need for further research to explore the causal mechanisms linking physical activity, irisin, and vascular calcification.

Frontiers In Endocrinology

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