Sequential ¹⁸F‑AV45/¹⁸F‑AV1451 dual‑tracer brain PET imaging in Alzheimer's disease: amyloid‑tau deposition, diagnostic performance, cognitive associations, and modulation by APOE ε4 - Takeaways - MDSpire

Sequential ¹⁸F‑AV45/¹⁸F‑AV1451 dual‑tracer brain PET imaging in Alzheimer's disease: amyloid‑tau deposition, diagnostic performance, cognitive associations, and modulation by APOE ε4

  • By

  • Hu, Guomei

  • Feng, Lijuan

  • He, Limeng

  • Liu, Nan

  • Wang, Hao

  • June 8, 2026

  • 0 min

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  • 1

    The study involved 438 participants, including 325 Alzheimer's disease patients, 68 mild cognitive impairment patients, and 45 healthy controls.

  • 2

    Sequential ¹⁸F‑AV45 and ¹⁸F‑AV1451 PET imaging showed significantly higher SUVRs in Alzheimer's patients compared to mild cognitive impairment and healthy controls.

  • 3

    The dual-tracer PET strategy demonstrated superior diagnostic efficacy for typical amnestic Alzheimer's disease, with AUC values of 0.97 and 0.93.

  • 4

    Tau deposition was found to have stronger cognitive correlations than amyloid-beta, with tau burden and APOE ε4 being independent predictors of cognitive impairment.

  • 5

    APOE ε4 carriers exhibited significantly higher amyloid and tau deposition, indicating its modulatory role in Alzheimer's disease pathology.

Original Source(s)

Sequential ¹⁸F‑AV45/¹⁸F‑AV1451 dual‑tracer brain PET imaging in Alzheimer's disease: amyloid‑tau deposition, diagnostic performance, cognitive associations, and modulation by APOE ε4

  • by Hu, Guomei , Feng, Lijuan , He, Limeng , Liu, Nan , Wang, Hao

  • June 8, 2026

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