Harmonization of social and physical health measures across prospective clinical studies of combat exposed service members and veterans: the total brain diagnostics program - Takeaways - MDSpire

Harmonization of social and physical health measures across prospective clinical studies of combat exposed service members and veterans: the total brain diagnostics program

  • By

  • Shannon M. Nugent

  • Kate Clauss

  • Sara Vlajic

  • Maya E. O’Neil

  • Samuel R. Walton

  • Kelly M. Reavis

  • Christine Clermont

  • Alyssa Currao

  • Cree Foeller

  • Catherine B. Fortier

  • Sreekanth Kamineni

  • Arielle R. Knight

  • Aubrey A. Knoff

  • Landon B. Lempke

  • Helal Mobasher

  • William C. Walker

  • William P. Milberg

  • David X. Cifu

  • July 8, 2026

  • 0 min

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  • 1

    Traumatic Brain Injury (TBI) is common among military personnel, leading to significant psychosocial and functional changes.

  • 2

    The study harmonized 73 psychosocial and physical health variables from two longitudinal studies, LIMBIC and TRACTS, involving veterans and service members.

  • 3

    Principal Component Analysis indicated that the harmonized data is suitable for pooled analysis across the two studies.

  • 4

    No significant differences in sex or ethnicity were found between participants in the LIMBIC and TRACTS studies.

  • 5

    The harmonization methods can be applied to longitudinal data to improve detection of clinical phenotypes in future research.

Original Source(s)

Harmonization of social and physical health measures across prospective clinical studies of combat exposed service members and veterans: the total brain diagnostics program

  • by Shannon M. Nugent, Kate Clauss, Sara Vlajic, Maya E. O’Neil, Samuel R. Walton, Kelly M. Reavis, Christine Clermont, Alyssa Currao, Cree Foeller, Catherine B. Fortier, Sreekanth Kamineni, Arielle R. Knight, Aubrey A. Knoff, Landon B. Lempke, Helal Mobasher, William C. Walker, William P. Milberg, David X. Cifu

  • July 8, 2026

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