Multimodal Imaging in Inherited Retinal Disorders - Takeaways - MDSpire

Multimodal Imaging in Inherited Retinal Disorders

As an increasing number of IRD patients are being identified and referred for genetic testing and counseling, clinicians would benefit from a practical and efficient framework for integrating multimodal imaging into their diagnoses and management. This review summarizes the utility of multimodal imaging across IRDs.

  • By

  • Jin Kyun (Luke) Oh, MD

  • Jesse D. Sengillo, MD

  • January 1, 2026

  • 12 min

Share

  • 1

    Multimodal imaging tools are essential for diagnosing and monitoring inherited retinal disorders (IRDs) due to their diverse genetic and phenotypic presentations.

  • 2

    Fundus photography and ultrawidefield imaging provide critical baseline documentation and can reveal peripheral abnormalities in diseases like retinitis pigmentosa.

  • 3

    Fundus autofluorescence (FAF) is particularly valuable for early diagnosis and monitoring of IRDs, detecting abnormalities not visible on standard examinations.

  • 4

    Serial measurements of decreased autofluorescence areas in Stargardt disease enable precise tracking of disease progression and are widely used in clinical trials.

  • 5

    Near-infrared autofluorescence (NIR-AF) complements conventional FAF by reliably detecting structural abnormalities and correlating with disease features.

Original Source(s)

Multimodal Imaging in Inherited Retinal Disorders

  • by Jin Kyun (Luke) Oh, MD, Jesse D. Sengillo, MD

  • January 1, 2026

Related Content

Troponin Screening and Major Cardiovascular Adverse Events During Immune Checkpoint Inhibitor Therapy

Durable response to ALK inhibition in low-allele-frequency SPTBN1–ALK–rearranged gastric cancer followed by lineage plasticity–mediated resistance: a case report

An FDG-first functional imaging approach in phaeochromocytoma and paraganglioma