Body Mass Index and Prognostic Nutritional Index as Indicators of Treatment Adherence and Survival Outcomes in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma Undergoing Sequential Chemoradiotherapy - Takeaways - MDSpire

Body Mass Index and Prognostic Nutritional Index as Indicators of Treatment Adherence and Survival Outcomes in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma Undergoing Sequential Chemoradiotherapy

  • By

  • Esra Zeynelgil

  • Engin Eren Kavak

  • İsmail Dilli

  • Özlem Aydın İsak

  • Doğan Yazılıtaş

  • Gökşen İnanç İmamoğlu

  • Ömer Bayır

  • December 15, 2025

  • 0 min

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  • 1

    Head and neck cancers account for 5-6% of male cancers in the U.S., with squamous cell carcinoma being the most prevalent type.

  • 2

    Induction chemotherapy followed by concurrent chemoradiotherapy may enhance treatment efficacy and organ function preservation in advanced HNSCC.

  • 3

    Toxicity from treatment can lead to decreased quality of life, treatment failure, and reduced survival in patients with HNSCC.

  • 4

    The study evaluates Body Mass Index (BMI) and Prognostic Nutritional Index (PNI) as predictors of treatment adherence and survival outcomes.

  • 5

    Statistical analyses were conducted using SPSS, with survival assessed via Kaplan-Meier and factors influencing treatment response analyzed through logistic regression.

Original Source(s)

Body Mass Index and Prognostic Nutritional Index as Indicators of Treatment Adherence and Survival Outcomes in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma Undergoing Sequential Chemoradiotherapy

  • by Esra Zeynelgil, Engin Eren Kavak, İsmail Dilli, Özlem Aydın İsak, Doğan Yazılıtaş, Gökşen İnanç İmamoğlu, Ömer Bayır

  • December 15, 2025

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