Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies - Takeaways - MDSpire

Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies

  • By

  • Keren Jia

  • Yang Chen

  • Die Dai

  • Yi Xie

  • Haoxin Peng

  • Yanshuo Cao

  • Hua Zou

  • Chuangzhao Qiu

  • Yan Tan

  • Xiaotian Zhang

  • Zhihao Lu

  • Xiaochen Yin

  • Zhi Peng

  • Jian Li

  • Lin Shen

  • January 12, 2026

  • 0 min

Share

  • 1

    Helicobacter pylori is a Group I carcinogen linked to gastric cancer, affecting approximately 40% of the global population.

  • 2

    H. pylori-positive gastric cancer patients show significantly longer immune-related progression-free survival compared to H. pylori-negative patients.

  • 3

    The gut microbiome's composition and diversity are influenced by H. pylori infection, impacting immune response and therapeutic outcomes.

  • 4

    Intratumoral microbiome is associated with gastric cancer prognosis and may mediate the effects of H. pylori on treatment response.

  • 5

    This study evaluates the role of H. pylori-driven microbiome changes in gastrointestinal cancer patients undergoing immunotherapy.

Original Source(s)

Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies

  • by Keren Jia, Yang Chen, Die Dai, Yi Xie, Haoxin Peng, Yanshuo Cao, Hua Zou, Chuangzhao Qiu, Yan Tan, Xiaotian Zhang, Zhihao Lu, Xiaochen Yin, Zhi Peng, Jian Li, Lin Shen

  • January 12, 2026

Related Content

SAGES colorectal and metabolic bariatric surgery committee joint task force call to action for synchronized severe obesity and colorectal cancer management

Dye-free versus dye-containing submucosal injection solutions in ESD for colorectal LST: a multi-center retrospective study on efficacy and safety

Error in Abstract

  • May 15, 2026