Comprehensive Genomic and Multi-Omics Approaches Reveal Oxidative Stress Pathways and Potential Therapeutic Targets for Tinnitus - Takeaways - MDSpire

Comprehensive Genomic and Multi-Omics Approaches Reveal Oxidative Stress Pathways and Potential Therapeutic Targets for Tinnitus

  • By

  • Jingjie Han

  • Ying Cao

  • Cai Zhang

  • Qianqian Zhang

  • Jinying Li

  • Hongen Xu

  • Xingle Zhao

  • Changyun Yu

  • April 28, 2026

  • 0 min

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  • 1

    Tinnitus is linked to oxidative stress, neuroinflammation, and metabolic abnormalities, affecting over 740 million people globally.

  • 2

    The study identified ACADVL as a key gene associated with tinnitus, showing increased expression in patients compared to healthy controls.

  • 3

    Oxidative stress influences immune and metabolic pathways, with ACADVL suppressing CD25 on specific B cells, increasing tinnitus risk.

  • 4

    Molecular docking analysis identified fenretinide as a potential therapeutic agent for tinnitus, highlighting its druggability.

  • 5

    The research integrates genetic, multi-omics, and experimental approaches to elucidate tinnitus mechanisms and identify therapeutic targets.

Original Source(s)

Comprehensive Genomic and Multi-Omics Approaches Reveal Oxidative Stress Pathways and Potential Therapeutic Targets for Tinnitus

  • by Jingjie Han, Ying Cao, Cai Zhang, Qianqian Zhang, Jinying Li, Hongen Xu, Xingle Zhao, Changyun Yu

  • April 28, 2026

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