Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025 - Takeaways - MDSpire

Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025

  • By

  • Shatha Ata Abdulgader

  • Ibrahim M. Aziz

  • Abdulhadi M. Abdulwahed

  • Mohamed A. Farrag

  • Reem M. Aljowaie

  • Abdulaziz M. Almuqrin

  • Noorah A. Alkubaisi

  • Fahad N. Almajhdi

  • February 19, 2026

  • 0 min

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  • 1

    Influenza A viruses, particularly A/H3N2, are highly contagious and cause significant public health challenges globally.

  • 2

    Antigenic drift in A/H3N2 viruses has led to frequent updates in vaccine components, yet effectiveness remains suboptimal.

  • 3

    Saudi Arabia's unique dynamics, including mass gatherings, contribute to the rapid transmission and mutation of influenza viruses.

  • 4

    This study aims to assess the prevalence and molecular characteristics of A/H3N2 strains in Riyadh for the 2024–2025 season.

  • 5

    Understanding the genetic and antigenic properties of circulating strains is crucial for effective vaccine policy and epidemic preparedness.

Original Source(s)

Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025

  • by Shatha Ata Abdulgader, Ibrahim M. Aziz, Abdulhadi M. Abdulwahed, Mohamed A. Farrag, Reem M. Aljowaie, Abdulaziz M. Almuqrin, Noorah A. Alkubaisi, Fahad N. Almajhdi

  • February 19, 2026

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