Emergence of Linezolid Resistance in Drug-Resistant Tuberculosis: Analyzing Genotype-Phenotype Discrepancies and Molecular Diversity in a Retrospective Study

1

Tuberculosis (TB) poses a significant global health threat, with 10.7 million new infections and 1.23 million deaths reported in 2024.
2

Linezolid resistance in drug-resistant TB strains is rising, with rates of 9%-15% in MDR-TB and up to 60% in XDR-TB cohorts.
3

Resistance primarily arises from ribosomal gene mutations and non-ribosomal mechanisms, complicating treatment strategies.
4

The study aimed to identify risk factors for acquired resistance and clarify genotype-phenotype correlations in linezolid treatment failure.
5

A retrospective analysis of patients with drug-resistant TB who failed linezolid regimens was conducted at Beijing Chest Hospital from 2017 to 2021.

Bmc Infectious Diseases

by Wenqiang Zhou, Qingfeng Wang, Wenjuan Nie, Wenhui Shi, Yang Yang, Wenjie Qi, Yu Lu, Naihui Chu
February 14, 2026

1