Severe asparaginase-associated hypertriglyceridemia in pediatric acute lymphoblastic leukemia: a single-center experience - Takeaways - MDSpire

Severe asparaginase-associated hypertriglyceridemia in pediatric acute lymphoblastic leukemia: a single-center experience

  • By

  • Maha Barbar

  • Dana Kanaan

  • Zebin AlZebin

  • Ammar Al Hmood

  • Sima Kalaldeh

  • Lana Amer

  • Saja Al Zghoul

  • Dana Aroury

  • June 23, 2026

  • 0 min

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  • 1

    Severe asparaginase-induced hypertriglyceridemia (AIHTG) occurred in 2% of pediatric ALL patients treated at King Hussein Cancer Center.

  • 2

    Most AIHTG cases were asymptomatic, detected incidentally through routine lab tests, with only two patients showing symptoms.

  • 3

    The median peak triglyceride level in affected patients was 2,645 mg/dL, with some exceeding 6,000 mg/dL.

  • 4

    Management included intravenous fluids, omega-3 fatty acids, fibrates, and insulin infusion, with plasmapheresis used in three patients.

  • 5

    Asparaginase was resumed in eight patients after AIHTG, with one recurrence; four patients required permanent discontinuation due to complications.

Original Source(s)

Severe asparaginase-associated hypertriglyceridemia in pediatric acute lymphoblastic leukemia: a single-center experience

  • by Maha Barbar, Dana Kanaan, Zebin AlZebin, Ammar Al Hmood, Sima Kalaldeh, Lana Amer, Saja Al Zghoul, Dana Aroury

  • June 23, 2026

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