Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation - Takeaways - MDSpire

Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation

  • By

  • Zhenqian Zhou

  • Dianhui Peng

  • Ping Peng

  • Xiaolin Li

  • July 15, 2026

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  • 1

    Autism spectrum disorder (ASD) is characterized by differences in social communication, motor function, and sensory processing.

  • 2

    Exercise interventions show potential benefits for various ASD-related outcomes, including motor performance and social functioning.

  • 3

    Existing literature often treats exercise as a generic intervention, lacking specificity in defining effective therapeutic elements.

  • 4

    Developmental stage and sex differences in exercise responses for ASD are underexplored, particularly for adolescents and females.

  • 5

    Clinical translation of exercise interventions in ASD is limited by short study durations, small sample sizes, and participation barriers.

Original Source(s)

Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation

  • by Zhenqian Zhou, Dianhui Peng, Ping Peng, Xiaolin Li

  • July 15, 2026

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