Advanced Versus Invasive Breast Cancer Risk in a Screening Population: Implications for Risk-based Prevention and Screening Strategies - Takeaways - MDSpire

Advanced Versus Invasive Breast Cancer Risk in a Screening Population: Implications for Risk-based Prevention and Screening Strategies

  • By

  • Brian L. Sprague

  • Charlotte C. Gard

  • Shuai Chen

  • Jeffrey A. Tice

  • Anna N. A. Tosteson

  • Hannah Perry

  • Christoph I. Lee

  • Diana L. Miglioretti

  • Karla Kerlikowske

  • February 18, 2026

  • 0 min

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  • 1

    The study aims to enhance breast cancer prevention and screening through risk-based strategies using advanced and invasive cancer risk models.

  • 2

    The BCSC developed a risk prediction model for advanced breast cancer, estimating a woman's 6-year risk of developing stage II or greater cancer.

  • 3

    Existing risk models primarily predict invasive breast cancer risk but are more accurate for estrogen receptor-positive cancers with high survival rates.

  • 4

    The study utilized data from 165 healthcare facilities, representing diverse demographics, to analyze breast cancer risk in a mammography screening population.

  • 5

    Women’s advanced and invasive breast cancer risks were computed and categorized, aiding in identifying those at risk for poor outcomes despite screening.

Original Source(s)

Advanced Versus Invasive Breast Cancer Risk in a Screening Population: Implications for Risk-based Prevention and Screening Strategies

  • by Brian L. Sprague, Charlotte C. Gard, Shuai Chen, Jeffrey A. Tice, Anna N. A. Tosteson, Hannah Perry, Christoph I. Lee, Diana L. Miglioretti, Karla Kerlikowske

  • February 18, 2026

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