Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning - Takeaways - MDSpire

Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning

  • By

  • Li Zhao

  • Xiang Jiang Meng

  • Xu Liang

  • Guang Mei Yuan

  • Li Shi

  • May 25, 2026

  • 0 min

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  • 1

    Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) affects 1-4% of the population and is often associated with asthma, leading to significant treatment challenges.

  • 2

    The study identified 21 differentially expressed genes related to metabolic reprogramming in CRSwNP, with 8 hub genes showing high diagnostic potential.

  • 3

    A prediction model using the identified biomarkers achieved a high diagnostic performance with an AUC of 0.979, indicating strong potential for clinical application.

  • 4

    Single-cell RNA sequencing revealed distinct expression patterns of metabolic genes across immune cell subsets, highlighting their role in CRSwNP.

  • 5

    The findings suggest that metabolic reprogramming plays a crucial role in CRSwNP pathogenesis, offering new avenues for diagnosis and targeted therapies.

Original Source(s)

Diagnostic value and immune microenvironment regulatory network of metabolic reprogramming in chronic rhinosinusitis with nasal polyps identified by multidimensional transcriptome integration and machine learning

  • by Li Zhao, Xiang Jiang Meng, Xu Liang, Guang Mei Yuan, Li Shi

  • May 25, 2026

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