Feasibility and safety of an analgesia-first strategy without hypnotic sedatives in adult patients admitted to the intensive care unit after neurosurgical craniotomy: a protocol for a single-arm, single-center exploratory prospective study - Takeaways - MDSpire

Feasibility and safety of an analgesia-first strategy without hypnotic sedatives in adult patients admitted to the intensive care unit after neurosurgical craniotomy: a protocol for a single-arm, single-center exploratory prospective study

  • By

  • Yu-Mei Wang

  • Ying Tian

  • Shu-Ya Wang

  • Guang-Qiang Chen

  • Guang-Zhi Shi

  • June 10, 2026

  • 0 min

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  • 1

    The study investigates an analgesia-first approach without hypnotic sedatives for adult neurosurgical ICU patients post-craniotomy.

  • 2

    A total of 65 patients will be enrolled, focusing on those with RASS scores ≥ +1 and anticipated ICU stays over 24 hours.

  • 3

    Primary endpoint includes successful protocol management within the first 24 hours, avoiding protocol failures and serious safety events.

  • 4

    Key safety endpoints encompass significant agitation, accidental extubation, respiratory depression, and neurological deterioration.

  • 5

    The study aims to evaluate the feasibility and safety of remifentanil-based analgesia in neurocritical care settings.

Original Source(s)

Feasibility and safety of an analgesia-first strategy without hypnotic sedatives in adult patients admitted to the intensive care unit after neurosurgical craniotomy: a protocol for a single-arm, single-center exploratory prospective study

  • by Yu-Mei Wang, Ying Tian, Shu-Ya Wang, Guang-Qiang Chen, Guang-Zhi Shi

  • June 10, 2026

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