Efficacy and safety of PARP inhibitors in older patients with advanced ovarian cancer: a systematic review and network meta-analysis - Takeaways - MDSpire

Efficacy and safety of PARP inhibitors in older patients with advanced ovarian cancer: a systematic review and network meta-analysis

  • By

  • Lei Liang

  • Bo Yang

  • Yuanyuan Wu

  • Jing-Lei Liu

  • Rongna Liu

  • Li Sun

  • July 9, 2026

  • 0 min

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  • 1

    Older adults with advanced ovarian cancer are underrepresented in randomized clinical trials, limiting age-specific evidence on PARP inhibitors.

  • 2

    The network meta-analysis included 13 RCTs and found significant improvements in progression-free survival for PARP inhibitors in both younger and older patients.

  • 3

    Olaparib, rucaparib, and niraparib showed significant progression-free survival benefits in older patients aged 65 years and above.

  • 4

    Niraparib was associated with increased odds of treatment-emergent adverse events, while olaparib and niraparib had higher risks of grade ≥3 anaemia.

  • 5

    The study highlights the need for further research on geriatric outcomes, long-term safety, and patient-reported outcomes in older patients.

Original Source(s)

Efficacy and safety of PARP inhibitors in older patients with advanced ovarian cancer: a systematic review and network meta-analysis

  • by Lei Liang, Bo Yang, Yuanyuan Wu, Jing-Lei Liu, Rongna Liu, Li Sun

  • July 9, 2026

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