Identification of biomarkers for predicting new-onset atrial fibrillation: a systematic review and meta-analysis - Takeaways - MDSpire

Identification of biomarkers for predicting new-onset atrial fibrillation: a systematic review and meta-analysis

  • By

  • Darío Mandaglio-Collados

  • María Pilar Ramos-Bratos

  • José Miguel Rivera-Caravaca

  • Eva Soler-Espejo

  • Vanessa Roldán

  • Gregory Y H Lip

  • Raquel López-Gálvez

  • Francisco Marín

  • January 29, 2026

  • 0 min

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  • 1

    A systematic review identified 18 biomarkers associated with increased risk of new-onset atrial fibrillation (AF), with NT-proBNP and sVCAM-1 being the most notable.

  • 2

    The meta-analysis revealed that elevated NT-proBNP levels significantly correlate with a higher incidence of AF, with a pooled hazard ratio of 1.37.

  • 3

    Nine biomarkers, including ADAMTS13, were linked to a lower incidence of AF, indicating potential protective factors.

  • 4

    The study included 10 cohort studies with 472,581 patients, of which 35,271 (7.5%) experienced new-onset AF.

  • 5

    Large-scale prospective studies are necessary to validate the diagnostic utility of identified biomarkers in predicting new-onset AF.

Original Source(s)

Identification of biomarkers for predicting new-onset atrial fibrillation: a systematic review and meta-analysis

  • by Darío Mandaglio-Collados, María Pilar Ramos-Bratos, José Miguel Rivera-Caravaca, Eva Soler-Espejo, Vanessa Roldán, Gregory Y H Lip, Raquel López-Gálvez, Francisco Marín

  • January 29, 2026

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