Remimazolam Is Associated with Superior Cerebral and Pulmonary Protection over Propofol in Elderly Thoracic Surgery: A Real-World Study Validated by Propensity Score Matching - Takeaways - MDSpire

Remimazolam Is Associated with Superior Cerebral and Pulmonary Protection over Propofol in Elderly Thoracic Surgery: A Real-World Study Validated by Propensity Score Matching

  • By

  • Zhang, Jingjing

  • Zhang, Xiaoyan

  • Cao, Na

  • Cai, Yichao

  • Zhao, Caixia

  • Tang, Chunying

  • Ma, Zhenhua

  • Zhang, Yan

  • May 6, 2026

  • 0 min

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  • 1

    This study compared remimazolam and propofol in elderly patients undergoing elective VATS lobectomy using propensity score matching.

  • 2

    The matched cohort of 244 patients showed superior cognitive recovery in the remimazolam group at multiple postoperative time points.

  • 3

    Remimazolam was associated with better pulmonary function at 72 hours, evidenced by higher FEV₁% predicted and lower lung ultrasound scores.

  • 4

    Patients receiving remimazolam exhibited enhanced hemodynamic and cerebral oxygen stability during one-lung ventilation.

  • 5

    The remimazolam group had lower rates of postoperative delirium and pulmonary complications compared to the propofol group.

Original Source(s)

Remimazolam Is Associated with Superior Cerebral and Pulmonary Protection over Propofol in Elderly Thoracic Surgery: A Real-World Study Validated by Propensity Score Matching

  • by Zhang, Jingjing , Zhang, Xiaoyan , Cao, Na , Cai, Yichao , Zhao, Caixia , Tang, Chunying , Ma, Zhenhua , Zhang, Yan

  • May 6, 2026

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