The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers - Takeaways - MDSpire

The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers

  • By

  • Jie Li Rong

  • Yi Xiang Guan

  • Chun Yan Ge

  • Xiao Jiang Liu

  • Gui Lan Lu

  • Su Ya Cao

  • Cheng Guan

  • Rong Jin

  • May 21, 2026

  • 0 min

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  • 1

    The study evaluated the effects of combined hyperbaric oxygen therapy (HBOT) and systematic auditory stimulation (SAS) on comatose patients with severe traumatic brain injury (sTBI).

  • 2

    Patients receiving HBOT and SAS showed significantly greater improvements in consciousness measures compared to those receiving standard care alone at Day 28.

  • 3

    At 3 months, the HBOT+SAS group had better functional outcomes, with higher Glasgow Outcome Scale scores than the control group.

  • 4

    Serum biomarkers indicated reduced neuronal injury and increased neurotrophic activity in the HBOT+SAS group, supporting the clinical findings.

  • 5

    The study concluded that the combined regimen of HBOT and SAS improved recovery of consciousness and functional outcomes in comatose sTBI patients.

Original Source(s)

The awakening effect of hyperbaric oxygen therapy combined with systematic auditory stimulation in comatose patients with craniocerebral injury and its influence on serum biomarkers

  • by Jie Li Rong, Yi Xiang Guan, Chun Yan Ge, Xiao Jiang Liu, Gui Lan Lu, Su Ya Cao, Cheng Guan, Rong Jin

  • May 21, 2026

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