Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Efficacy Comparison of Statins, Metformin, and Vitamin D in Preeclampsia Prevention: A Systematic Review and Network Meta-Analysis of Randomized Trials

  • By

  • Menna Alaa El-Khouly

  • Mazen Mohammed Mahgoub

  • Mahmoud E. Abd-Elkareem

  • Noreen M. El-Bayaa

  • Jana M. Farouk

  • Mariam M. Fouad

  • Habiba Mohammed Salah

  • Ahmed Khaled Saad

  • Mohammed Al-azab

  • Rofida Ayman Mohamed

  • Kholoud Dahshan

  • Dalia Atef Abouda

  • October 2, 2026

Share

  • 1

    Preeclampsia affects 2%-8% of pregnancies and is linked to significant maternal and perinatal morbidity and mortality.

  • 2

    Current prevention strategies primarily involve low-dose aspirin, which may only reduce preterm-onset preeclampsia.

  • 3

    Statins, metformin, and vitamin D have been investigated as alternative agents for preeclampsia prevention.

  • 4

    The systematic review aimed to compare the efficacy of statins, metformin, and vitamin D in preventing preeclampsia.

  • 5

    The analysis followed PRISMA guidelines and included only randomized controlled trials of high-risk pregnant individuals.

Original Source(s)

Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials

  • by Menna Alaa El-Khouly, Mazen Mohammed Mahgoub, Mahmoud E. Abd-Elkareem, Noreen M. El-Bayaa, Jana M. Farouk, Mariam M. Fouad, Habiba Mohammed Salah, Ahmed Khaled Saad, Mohammed Al-azab, Rofida Ayman Mohamed, Kholoud Dahshan, Dalia Atef Abouda

  • October 2, 2026

Related Content

Early indicators of NICU admission for ongoing respiratory support in caesarean-delivered late preterm and term neonates requiring non-invasive respiratory support within the first 15 min after birth: a post hoc analysis

Laser Therapy for Sexual Health in Breast Cancer Survivors Receiving Aromatase Inhibitors: A Secondary

Abortion is on the ballot again as post-Roe policies continue to evolve

"I just think there's a constitutional crisis that's coming."