The role of LARP1 in breast cancer progression: from prognosis to immune microenvironment remodeling - Takeaways - MDSpire

The role of LARP1 in breast cancer progression: from prognosis to immune microenvironment remodeling

  • By

  • Yangtian Ye

  • Hong Yin

  • Xiangyu Shen

  • Fucheng Li

  • Luyao Liu

  • Dao Sun

  • June 16, 2026

  • 0 min

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  • 1

    LARP1 is overexpressed in breast cancer tissues and correlates with poor overall and progression-free survival outcomes.

  • 2

    LARP1 is involved in cell cycle progression, mitochondrial homeostasis, and immune modulation in breast cancer.

  • 3

    Silencing LARP1 reduces breast cancer cell proliferation, migration, and invasion while inducing mitochondrial dysfunction.

  • 4

    LARP1 downregulation shifts tumor-associated macrophages from an immunosuppressive M2 phenotype to a pro-inflammatory M1 phenotype.

  • 5

    LARP1 is a potential therapeutic target and biomarker for prognosis and immune response in breast cancer.

Original Source(s)

The role of LARP1 in breast cancer progression: from prognosis to immune microenvironment remodeling

  • by Yangtian Ye, Hong Yin, Xiangyu Shen, Fucheng Li, Luyao Liu, Dao Sun

  • June 16, 2026

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