A Molecular Map of Fabry Disease Combined Raman microscopy and AP-MALDI-MSI reveal localized Gb3 accumulation overlooked by bulk measurements and conventional staining August 4, 2026 3 min The Analytical Scientist Share Takeaways 1 A multimodal imaging workflow has mapped lipid accumulation in cardiac tissue related to Fabry disease. 2 Fabry disease is characterized by insufficient breakdown of globotriaosylceramides (Gb3), leading to lipid accumulation. 3 Raman microscopy and AP-MALDI mass spectrometry imaging were combined to identify and localize Gb3 lipoforms in cardiac tissue. 4 Gb3 accumulation in heart tissue from mouse models showed localized hotspots and distinct spatial patterns of different variants. 5 The research team plans to extend their imaging workflow to human tissue samples to better understand lipid distribution.
