Evaluation of Corneal and Tear Film Changes via Anterior Segment Optical Coherence Tomography Following Systemic Isotretinoin Therapy in Patients with Acne Vulgaris - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Evaluation of Corneal and Tear Film Changes via Anterior Segment Optical Coherence Tomography Following Systemic Isotretinoin Therapy in Patients with Acne Vulgaris

  • By

  • Mohamed Salah El-Din Mahmoud

  • Hosny Ahmed Zein

  • Mustafa Mohamed Al-Anwar

  • Ahmed Maher Khalafallah

  • November 19, 2025

Share

  • 1

    Isotretinoin is the most effective treatment for severe acne vulgaris, significantly reducing sebum production and inflammation.

  • 2

    Ocular side effects from isotretinoin include meibomitis, keratitis, and potential corneal opacities, impacting tear film and corneal health.

  • 3

    The study evaluated corneal epithelial thickness and tear film parameters using anterior segment optical coherence tomography (AS-OCT) in acne patients.

  • 4

    One hundred patients were monitored before, during, and after isotretinoin treatment to assess changes in corneal and tear film metrics.

  • 5

    Statistical analysis was performed using SPSS to evaluate the significance of changes in tear meniscus and corneal thickness measurements.

Original Source(s)

Evaluation of Corneal and Tear Film Changes via Anterior Segment Optical Coherence Tomography Following Systemic Isotretinoin Therapy in Patients with Acne Vulgaris

  • by Mohamed Salah El-Din Mahmoud, Hosny Ahmed Zein, Mustafa Mohamed Al-Anwar, Ahmed Maher Khalafallah

  • November 19, 2025

Related Content

Spondyloarthritis function varies by sex

Women had greater functional deterioration over 17 years, while permanent work disability did not differ significantly between sexes.

Rapidly progressive bilateral lens abnormalities following cataract surgery in a highly myopic patient

Artificial intelligence in ophthalmology: an invisible environmental footprint