Assessment of the rs6498486 Polymorphism in the ERCC4 (XPF) Gene and Its Possible Association with Breast Cancer Risk in Bangladeshi Women - Takeaways - MDSpire

Assessment of the rs6498486 Polymorphism in the ERCC4 (XPF) Gene and Its Possible Association with Breast Cancer Risk in Bangladeshi Women

  • By

  • Iffat Hossain

  • Sanjida Chowdhury Ivy

  • Mohammad Safiqul Islam

  • Mohammad Shahriar

  • February 17, 2026

  • 0 min

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  • 1

    Breast cancer is the most commonly diagnosed cancer among women worldwide, with various risk factors influencing its development.

  • 2

    The ERCC4 gene encodes the XPF endonuclease, crucial for DNA repair via the nucleotide excision repair pathway.

  • 3

    The rs6498486 polymorphism in the ERCC4 gene is associated with increased breast cancer risk, particularly in South Asian populations.

  • 4

    Functional variants in DNA repair genes like ERCC4 may affect genomic stability and individual susceptibility to breast cancer.

  • 5

    The study highlights the need for population-specific data to understand the role of ERCC4 variants in breast cancer risk.

Original Source(s)

Assessment of the rs6498486 Polymorphism in the ERCC4 (XPF) Gene and Its Possible Association with Breast Cancer Risk in Bangladeshi Women

  • by Iffat Hossain, Sanjida Chowdhury Ivy, Mohammad Safiqul Islam, Mohammad Shahriar

  • February 17, 2026

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